Neuropathology Core

The Neuropathology Core (NPC) focuses on the coordination of autopsies for patients enrolled in the CADRC. This includes the final diagnostic study, storage, and distribution of fixed and frozen brain tissue from longitudinally characterized patients enrolled in the CADRC.

The NPC is located at Case Western Reserve University, within the National Prion Disease Pathology Surveillance Center (NPDPSC). The NPDPSC has over two decades of experience with coordinating autopsies, collecting, characterizing, storing and distributing tissues from suspected prion disease cases across the U.S.

We work closely with the CADRC Clinical Core (CC) to enroll patients in the brain donation program.  Our autopsy coordinators assist families in obtaining the necessary data for a smooth autopsy coordination effort.  The tissues are then tested and diagnosed per NIA-AA criteria.

Researchers may also request tissue through the NPC biobank. Requests should be directed to NPC@ClevelandADRC.org

Personnel:

Dr. Mark Cohen, Director (Co-Director, National Prion Disease Pathology Surveillance Center)

Dr. Brian Appleby, Co-Director (Director, National Prion Disease Pathology Surveillance Center)

Dr. Jim Leverenz, Additional Neuropathology Review

Katie Glisic, Research Administrator

Danielle Jordan, Meghan Lewis, Amy Pickens, Autopsy Coordinators

Aaron Koeth, UH Mortician’s Office

UH & NPDPSC histology staff

CADRC Autopsy FAQ:

My loved one has passed, who do I contact?

If your loved one is registered for autopsy through the CADRC Clinical Core, please call the autopsy coordinators at 216-368-0587 to report the passing of the participant. We will contact you back directly to go over the process and any other information as needed. Please be sure to let the telephone operator know that this is a CADRC autopsy.

Where will the autopsy take place?

If the CADRC participant is located in Ohio, then the autopsy procedure will take place at the University Hospitals Cleveland Medical Center Campus, in Cleveland, Ohio. If the participant is not in Ohio, then we will utilize our network of providers to secure a location for the autopsy that is as close to the participant’s location as possible. In the event that an out-of-town provider must be used, the NPC will make all of the transportation arrangements and cover costs if necessary, and will work to complete the entire process as soon as possible. The NPC will keep you posted if delays are expected so that you can adjust your plans accordingly.

How long does the autopsy take?

The NPC will make every effort to have the procedure completed within a day. However, weekends and holidays can slow the process down. The autopsy procedure itself will take approximately 1 hour to complete.

What are the costs for the autopsy?

The autopsy will be provided free of charge, including transportation if necessary. Please note that the CADRC cannot cover funeral or embalming charges.

Is the body returned to the family/funeral home after the autopsy?

 After the autopsy is complete, the body will be returned to the funeral home and the family can proceed with their funeral preparations. 

How will I be notified of results?

Your Clinical Core physician should reach out to you when the results are ready.

For more general information about brain donations, please see https://www.nia.nih.gov/health/brain-donation-gift-future-generations