The CYCLE‐AD (CYcling to Cease or Limit the Effects of Alzheimer’s Disease) project is a 5-year research grant from the U.S. National Institute of Health (NIH), which has been awarded to Drs. Rao and Alberts. It is a randomized controlled trial which aims to study the impact of a home based, high intensity exercise program in healthy older adults between the ages of 65 and 80 years, who have a genetic risk for Alzheimer’s disease (AD) but do not have any memory concerns.
The CYCLE-AD trial will recruit healthy sedentary APOE e4 carriers and randomize them to one of two groups: 1) an Indoor Cycling (IC) group that participates in high-intensity interval training in their home using a commercially available Peloton® cycling system or 2) a Usual and Customary Care (UCC) group, in which participants engage in their habitual level of physical activity. View study flyer here.
This trial is being conducted at the Cleveland Clinic Lou Ruvo Center for Brain Health in Cleveland, Ohio. All study visits and appointments will occur at the Mellen Center on the Main Campus of Cleveland Clinic.
From The Wisconsin Alzheimer’s Institute:
“Determined: Fighting Alzheimer’s”
Documentary Premiered on PBS 4/6/2022
“Filmed over five years, DETERMINED is an independent documentary portraying the stories of three women and their decision to participate in Alzheimer’s disease research. The film features research participants and scientists at Wisconsin Registry for Alzheimer’s Prevention (WRAP). Find out more about the NOVA premiere on the PBS website.”
Where to watch: https://www.pbs.org/video/determined-fighting-alzheimers-3ohltv/
Link to article: https://wai.wisc.edu/2022/03/02/watch-determined-on-nova-on-april-6/
Have you or a family member been diagnosed with dementia, such as Alzheimer’s Disease or Lewy Body Dementia?
Are you over 18 years old?
If you answered yes to the questions above, you may be eligible to participate in a research study.
Researchers from Case Western Reserve University, Cleveland Clinic, MetroHealth, University Hospitals and the Louis Stokes Cleveland VA Medical Center have joined together to form The Cleveland Alzheimer’s Disease Research Center (CADRC) which aims to study the different forms of dementia in the hope that learning more about the disease can lead to new forms of treating, and eventually curing, Alzheimer’s and related disorders.
Study participants will take part in cognitive testing, blood draws, physical exams, imaging scans, and other selective procedures. Follow up visits will occur annually. Compensation for completed study visits will be provided.
If you are interested in finding out more information for yourself or someone you know, please call the toll free number at:
Or click on the link below to send us your contact information and a member of the study team will reach out to you:
More ways to get involved with the CADRC are coming soon!