Neuropathology Core Co-Leader

Brian Appleby, MD

Director, National Prion Disease Pathology Surveillance Center

Associate Professor of Neurology, Psychiatry and Pathology, Case Western Reserve University

Medical Director, CJD Foundation

Chair, Professional Advisory Board, Cleveland Alzheimer’s Association

Dr. Appleby is an Associate Professor of Neurology, Psychiatry, and Pathology at Case Western Reserve University.  Dr. Appleby received a B.A. in biology and philosophy from Goucher College and a M.D. from Georgetown University School of Medicine.  He completed a psychiatry residency and geriatric psychiatry fellowship at The Johns Hopkins Hospital.  He currently serves as the Director of the National Prion Disease Pathology Surveillance Center, as Medical Director of the CJD Foundation, and Chair of the Cleveland Alzheimer’s Association Chapter’s Professional Advisory Board.  He sees patients at University Hospitals Foley Elderhealth Center.

His research and clinical interests include young onset and atypical dementias, specifically prion diseases and frontotemporal lobar degeneration.  Dr. Appleby has several projects examining the clinical and translational aspects of prion diseases.  In particular, he is interested in improving diagnosis, developing diagnostic tests and biomarkers, and surveilling for novel prion diseases (e.g., possible chronic wasting disease in humans).  He is also a site principle investigator for Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL), a multisite study for clinical research in frontotemporal lobar degeneration.