The CLARiTI study recently reached a major milestone, surpassing its enrollment goal for the current grant year. By August 2026, teams at University Hospitals and Cleveland Clinic had enrolled 33 participants, including 19 individuals with cognitive impairment. The study also exceeded its target for enrollment from underrepresented populations, with 42% of participants coming from those groups.

CLARiTI, the Consortium for Clarity in ADRD Research Through Imaging, is a nationwide research initiative focused on collecting detailed imaging and biomarker data from participants already enrolled in Alzheimer's disease and related dementia research studies. At the local level, CLARiTI works with CADRC participants at both University Hospitals and Cleveland Clinic.

Participants in CLARiTI complete a series of scans and assessments designed to capture information about changes occurring in the brain. These imaging data are combined with blood-based biomarkers and other research data to create a more complete picture of cognitive impairment and disease progression.

The enrollment milestone reflects months of recruitment, scheduling, and coordination across both sites. Reaching enrollment targets is essential because the value of the dataset depends on having enough participants and ensuring that the population studied reflects the communities affected by these conditions. The study's enrollment of participants from underrepresented populations greatly exceeded the original goal, resulting in a dataset that includes a broader range of participant experiences.

The information collected through CLARiTI supports a larger effort to build a shared research resource for scientists studying Alzheimer's disease and related dementias. Researchers can use these imaging and biomarker data to examine how changes in the brain relate to cognition, compare findings across different studies, and explore patterns that emerge over time.

For the CADRC, participation in CLARiTI expands the opportunities available to research volunteers while contributing data that can be used by investigators throughout the broader Alzheimer's research community. Because participants are followed over time, the project adds depth to ongoing efforts to understand how cognitive changes develop and progress.

Enrollment for the current grant year concluded in August 2026. The team is currently awaiting the next year's subaward so enrollment can continue at University Hospitals and Cleveland Clinic. In the meantime, participants enrolled this year continue to complete their imaging visits and assessments.

The data collected through CLARiTI will support future studies both within the CADRC and across the broader research community. Researchers will be able to use these imaging and biomarker data alongside other study data to examine changes associated with cognitive impairment and dementia over time.